Ovarian volume partially explains associations of phthalate biomarkers with anti-Mullerian hormone and estradiol in midlife women.

ABSTRACT:

Background/objectives

Women are ubiquitously exposed to endocrine disruptors, including phthalates. Ovarian follicles undergoing folliculogenesis (indirectly measured by ovarian volume) produce anti-Müllerian hormone (AMH) and estradiol (E2). We evaluated associations of phthalates with ovarian volume to assess whether this explained prior positive associations of phthalates with AMH and E2.

Methods

Women ages 45-54 years (n = 614) had transvaginal ultrasounds of right/left ovaries to calculate mean ovarian volume. Women provided up-to-four urine and blood samples for quantifying AMH (first serum sample), E2 (all serum samples), and nine phthalate metabolites (from pooled urine, representing six parent phthalates). Multivariable linear or logistic regression models (for indi

SUBMITTER: Cinzori ME 

PROVIDER: S-EPMC10012419 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature