Polysubstance use before and during treatment with medication for opioid use disorder: Prevalence and association with treatment outcomes.

ABSTRACT:

Objective

Polysubstance use may complicate treatment outcomes for individuals who use opioids. This research aimed to examine the prevalence of polysubstance use in an opioid use disorder treatment trial population and polysubstance use's association with opioid relapse and craving.

Methods

This study is a secondary data analysis of individuals with opioid use disorder who received at least one dose of medication (n = 474) as part of a 24-week, multi-site, open label, randomized Clinical Trials Network study (CTN0051, X:BOT) comparing the effectiveness of extended-release naltrexone versus buprenorphine. Models examined pretreatment polysubstance use and polysubstance use during the initial 4 weeks of treatment on outcomes of relapse by week 24 of the treatment trial and opi

SUBMITTER: Bunting AM 

PROVIDER: S-EPMC10012431 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature