New insights into the impact of microbiome on horizontal and vertical transmission of a tick-borne pathogen.

ABSTRACT:

Background

The impact of host skin microbiome on horizontal transmission of tick-borne pathogens , and of pathogen associated transstadial and transovarial changes in tick microbiome are largely unknown, but are important to control increasingly emerging tick-borne diseases worldwide.

Methods

Focusing on a rickettsiosis pathogen, Rickettsia raoultii, we used R. raoultii-positive and R. raoultii-negative Dermacentor spp. tick colonies to study the involvement of skin microbiota in cutaneous infection with rickettsiae in laboratory mice, and the function of the tick microbiome on maintenance of rickettsiae through all tick developmental stages (eggs, larvae, nymphs, adults) over two generations.

Results

We observed changes in the skin bacteria community, such as Chlamyd

SUBMITTER: Du LF 

PROVIDER: S-EPMC10012463 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature