De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation.

ABSTRACT:

Background

Macroautophagy is an essential cellular self-protection mechanism, and defective autophagy has been considered to contribute to a variety of diseases. During the process, cytoplasmic components are transported via autophagosomes to acidic lysosomes for metabolism and recycling, which represents application niches for lysosome-targeted fluorescent probes. Additionally, in view of the complexity of the autophagy pathway, it entails more stringent requirements for probes suitable for monitoring autophagy. Meanwhile, aggregation-induced emission (AIE) fluorescent probes have been impressively demonstrated in the biomedical field, which bring fascinating possibilities to the autophagy visualization.

Methods

We reported a generalizable de novo design of a novel pH-sensi

SUBMITTER: Huang X 

PROVIDER: S-EPMC10012510 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature