IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer's disease.

ABSTRACT:

Background

Systemic activation of the immune system can exert detrimental effects on the central nervous system. Periodontitis, a chronic disease of the oral cavity, is a common source of systemic inflammation. Neuroinflammation might be a result of this to accelerate progressive deterioration of neuronal functions during aging or exacerbate pre-existing neurodegenerative diseases, such as Alzheimer's disease. With advancing age, the progressive increase in the body's pro-inflammatory status favors the state of vulnerability to both periodontitis and Alzheimer's disease. In the present study, we sought to delineate the roles of cytokines in the pathogenesis of both diseases.

Methods

To examine the impacts of periodontitis on the onset and progression of Alzheimer's disease,

SUBMITTER: Wang RP 

PROVIDER: S-EPMC10012546 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature