Quantitative proteomics identifies and validates urinary biomarkers of rhabdomyosarcoma in children.

ABSTRACT:

Background

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma with poor prognosis in children. The 5-year survival rate for early RMS has improved, whereas it remains unsatisfactory for advanced patients. Urine can rapidly reflect changes in the body and identify low-abundance proteins. Early screening of tumor markers through urine in RMS allows for earlier treatment, which is associated with better outcomes.

Methods

RMS patients under 18 years old, including those newly diagnosed and after surgery, were enrolled. Urine samples were collected at the time points of admission and after four cycles of chemotherapy during follow-up. Then, a two-stage workflow was established. (1) In the discovery stage, differential proteins (DPs) were initially identified in 43 RMS

SUBMITTER: Xu N 

PROVIDER: S-EPMC10012572 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature