Conservation and divergence of canonical and non-canonical imprinting in murids.

ABSTRACT:

Background

Genomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and behavior. While the rat is widely used to model human pathophysiology, few imprinted genes have been identified in this murid. To systematically identify imprinted genes and genomic imprints in the rat, we use low input methods for genome-wide analyses of gene expression and DNA methylation to profile embryonic and extraembryonic tissues at allele-specific resolution.

Results

We identify 14 and 26 imprinted genes in these tissues, respectively, with 10 of these genes imprinted in both tissues. Comparative analyses with mouse reveal that orthologous imprinted gene expression and associated canonical DNA methylation imprints are co

SUBMITTER: Richard Albert J 

PROVIDER: S-EPMC10012579 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature