Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients.

ABSTRACT:

Background

To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma.

Methods

We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy controls.

Results

The plasma exosome-derived Cx43 levels in patients with melanoma were substantially downregulated as opposed to the levels in healthy controls (P < 0.001). Kaplan-Meier analysis indicated that overall survival (OS) and disease-free survival (DFS) were poorer in patients with melanoma who exhibited lower levels of plasma exosome-derived Cx43 (both P < 0.001). The levels of plasma exosome-derived Cx43 were considerably elevated in patients with melanoma whose tumor was situated in the skin, tumor size < 

SUBMITTER: Shen Y 

PROVIDER: S-EPMC10012581 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature