Multilayered blow-spun vascular prostheses with luminal surfaces in Nano/Micro range: the influence on endothelial cell and platelet adhesion.

ABSTRACT:

Background

In this study, two types of polyurethane-based cylindrical multilayered grafts with internal diameters ≤ 6 mm were produced by the solution blow spinning (SBS) method. The main aim was to create layered-wall prostheses differing in their luminal surface morphology. Changing the SBS process parameters, i.e. working distance, rotational speed, volume, and concentration of the polymer solution allowed to obtain structures with the required morphologies. The first type of prostheses, termed Nano, possessed nanofibrous luminal surface, and the second type, Micro, presented morphologically diverse luminal surface, with both solid and microfibrous areas.

Results

The results of mechanical tests confirmed that designed prostheses had high flexibility (Young's modulus value

SUBMITTER: Lopianiak I 

PROVIDER: S-EPMC10012602 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature