Overlapping SigH and SigE sigma factor regulons in Corynebacterium glutamicum.

ABSTRACT: The sigma H (σ^Η) and sigma E (σ^E) subunits of Corynebacterium glutamicum RNA polymerase belong to Group 4 of sigma factors, also called extracytoplasmic function (ECF) sigma factors. Genes of the C. glutamicum σ^Η regulon that are involved in heat and oxidative stress response have already been defined, whereas the genes of the σ^E regulon, which is involved in cell surface stress response, have not been explored until now. Using the C. glutamicum RES167 strain and its derivative C. glutamicum ΔcseE with a deletion in the anti-σ^Ε gene, differential gene expression was analyzed by RNA sequencing. We found 296 upregulated and 398 downregulated genes in C. glutamicum ΔcseE compared to C. g

SUBMITTER: Busche T 

PROVIDER: S-EPMC10012870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature