The potential role of serum extracellular vesicle derived small RNAs in AML research as non-invasive biomarker.

ABSTRACT:

Background

Extracellular vesicles (EV) are cell-derived vesicles released by all cells in health and disease. Accordingly, EVs are also released by cells in acute myeloid leukemia (AML), a hematologic malignancy characterized by uncontrolled growth of immature myeloid cells, and these EVs likely carry markers and molecular cargo reflecting the malignant transformation occurring in diseased cells. Monitoring antileukemic or proleukemic processes during disease development and treatment is essential. Therefore, EVs and EV-derived microRNA (miRNA) from AML samples were explored as biomarkers to distinguish disease-related patterns ex vivo or in vivo.

Methodology

EVs were purified from serum of healthy (H) volunteers and AML patients by immunoaffinity. EV surface p

SUBMITTER: Li L 

PROVIDER: S-EPMC10012871 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature