Prognosis and Survival Modelling in Cirrhosis Using Parenclitic Networks.

ABSTRACT: Background: Liver cirrhosis involves multiple organ systems and has a high mortality. A network approach to complex diseases often reveals the collective system behaviours and intrinsic interactions between organ systems. However, mapping the functional connectivity for each individual patient has been challenging due to the lack of suitable analytical methods for assessment of physiological networks. In the present study we applied a parenclitic approach to assess the physiological network of each individual patient from routine clinical/laboratory data available. We aimed to assess the value of the parenclitic networks to predict survival in patients with cirrhosis. Methods: Parenclitic approach creates a network from the perspective of an individual subject in a population

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10013061 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature