A near infrared fluorescent probe for rapid sensing of peroxynitrite in living cells and breast cancer mice.

ABSTRACT: Peroxynitrite (ONOO^-) plays an essential role in numerous physiological and pathological processes owing to its strong oxidation and nitrification. Many studies have shown that ONOO^- abnormalities are associated with inflammatory diseases, even cancer, such as arthritis, hepatitis, pneumonia, and breast cancer. Thus, developing a trustworthy technology to monitor ONOO^- levels is critical in inflammatory or cancer illnesses. Herein, an ultrafast near-infrared (NIR) fluorescent probe (Cy-OH-ONOO) is proposed to detect ONOO^- within 30 s. The probe's borate moiety is oxidized and separated from Cy-OH-ONOO, releasing a NIR fluorescence signal after interacting with ONOO^- under physiological circumstances. In addition, the probe displays goo

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10013131 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature