Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice.

ABSTRACT:

Introduction

Cordycepin has been reported to exhibit hepatic protective and anti-inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)-induced liver injury in a mouse model.

Methods

Mice were pretreated with cordycepin by gavage for 3 weeks, followed by the establishment of the IR modeling. Liver injury, Suzuki's histological grading, hepatic apoptosis, and inflammatory responses were evaluated by biochemical and pathological analysis.

Results

It was found that Cordycepin pretreatment at 50 mg/kg for 3 weeks attenuated IR-induced liver injury, as reflected by the significant decrease of the levels of aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, and low-density lipoprotein. Cordycepin pretreatment

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10013135 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature