Diurnal variability of cortisol in the Pennsylvania adult smoking study: Exploration of association with nicotine intake.

ABSTRACT: Cortisol in saliva, urine and plasma follows a diurnal rhythm typically characterized as a morning peak and a decline throughout the waking day. While often measured under controlled conditions, inter-individual differences in cortisol diurnal rhythms in free living populations are not well characterized. Cortisol levels may vary substantially between individuals and the level of variation may differ depending on the time of day. Further, associations with individual characteristics such as nicotine dependence on cortisol rhythms have not been adequately determined. We developed a Liquid Chromatography-Tandem Mass Spectrometry method to measure cortisol in saliva of 180 smokers from the Pennsylvania Adult Smoking Study. Diurnal patters of cortisol were determined by obtaining five timed sa

SUBMITTER: Machiorlatti M 

PROVIDER: S-EPMC10013170 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature