ROS-Responsive Glycopolymeric Nanoparticles for Enhanced Drug Delivery to Macrophages.

ABSTRACT: Macrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular diseases, and cancer. However, many therapeutic strategies targeting macrophages suffer from systemic off-target toxicity resulting in notoriously narrow therapeutic windows. To address this shortcoming, the development of poly(propylene sulfide)-b-poly(methacrylamidoglucopyranose) [PPS-b-PMAG] diblock copolymer-based nanoparticles (PMAG NPs) capable of targeting macrophages and releasing drug in the presence of reactive oxygen species (ROS) is reported. PMAG NPs have desirable physicochemical properties for systemic drug delivery, including slightly negative surface charge, ≈100 nm diameter, and hemo-compatibility. Additionally, due to the presence of PPS in the NP core, PMAG NPs rele

SUBMITTER: Shofolawe-Bakare OT 

PROVIDER: S-EPMC10013198 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature