Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients.

ABSTRACT:

Objective

To evaluate whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19.

Methods

We present a post hoc analysis from a double-blinded placebo-controlled randomized clinical trial (RCT) on the effect of colchicine for the treatment of COVID-19. Serum levels of NOD-like receptor protein 3 (NLRP3) inflammasome products-active caspase-1 (Casp1p20), IL-1β, and IL-18-were assessed at enrollment and after 48-72 h of treatment in patients receiving standard-of-care (SOC) plus placebo vs. those receiving SOC plus colchicine. The colchicine regimen was 0.5 mg tid for 5 days, followed by 0.5 mg bid for another 5 days.

Results

Thirty-six patients received SOC plus colchicine, and thirty-six received SOC plus

SUBMITTER: Amaral NB 

PROVIDER: S-EPMC10013297 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature