TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway.

ABSTRACT:

Introduction

Thyroid cancer has received increasing attention; however, its detailed pathogenesis and pathological processes remain unclear. We investigated the role of TANK-binding kinase 1 (TBK1) in the progression of thyroid cancer.

Methods

The expression of TBK1 in thyroid cancer and normal control tissues was analyzed using real-time quantitative polymerase chain reaction. The function of TBK1 on thyroid cancer cells was detected using MTT, colony formation, wound healing, and Transwell assays. The xenograft assay was carried out to check on the role of TBK1 in thyroid cancer.

Results

TBK1 was highly expressed in thyroid tumors. High expression of TBK1 raised viability, proliferation, migration, and invasion of thyroid cancer cells. Gene set enrichment analysis r

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC10013413 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature