Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.

ABSTRACT:

Background

Meningiomas, the most common primary intracranial tumors, can be separated into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and therapeutic vulnerabilities. Alternative meningioma grouping schemes using copy number variants, gene expression profiles, somatic short variants, or integrated molecular models have been proposed. These data suggest meningioma DNA methylation groups may harbor subgroups unifying contrasting theories of meningioma biology.

Methods

A total of 565 meningioma DNA methylation profiles from patients with comprehensive clinical follow-up at independent discovery (n = 200) or validation (n = 365) institutions were reanalyzed and classified into Merlin-intact, Immune-enriched, or Hypermitotic DNA methylation grou

SUBMITTER: Choudhury A 

PROVIDER: S-EPMC10013643 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature