AFTM: a database of transmembrane regions in the human proteome predicted by AlphaFold.

ABSTRACT: Transmembrane proteins (TMPs), with diverse cellular functions, are difficult targets for structural determination. Predictions of TMPs and the locations of transmembrane segments using computational methods could be unreliable due to the potential for false positives and false negatives and show inconsistencies across different programs. Recent advances in protein structure prediction methods have made it possible to identify TMPs and their membrane-spanning regions using high-quality structural models. We developed the AlphaFold Transmembrane proteins (AFTM) database of candidate human TMPs by identifying transmembrane regions in AlphaFold structural models of human proteins and their domains using the positioning of proteins in membranes, version 3 program, followed by automatic correct

SUBMITTER: Pei J 

PROVIDER: S-EPMC10013729 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature