Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression.

ABSTRACT: Engagement of the inhibitory T cell receptor programmed cell death protein 1 (PD-1) associates with dysfunctional states of pathogen- or tumor-specific T cells. Accordingly, systemic antibody-mediated blockade of PD-1 has become a central target for immunotherapies but is also associated with severe toxicities due to loss of peripheral tolerance. Therefore, selective ablation of PD-1 expression on adoptively transferred T cells through direct genetic knockout (KO) is currently being explored as an alternative therapeutic approach. However, since PD-1 might also be required for the regulation of physiological T cell function and differentiation, the suitability of PD-1 as an engineering target is controversial. In this study, we systematically investigated the maintenance of T cell function

SUBMITTER: Dotsch S 

PROVIDER: S-EPMC10013756 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature