Intraosseous administration into the skull: Potential blood-brain barrier bypassing route for brain drug delivery.

ABSTRACT: Progress in treating central nervous system (CNS) disorders is retarded owing to a limited understanding of brain disease pathology. Additionally, the blood-brain barrier (BBB) limits molecular entry into the brain. Many approaches for brain drug delivery to overcome the BBB, such as BBB permeability enhancement, transient BBB disruption, and direct surgical administration have been explored with limited success. Recent research has shown that direct vascular channels exist between the skull bone marrow and the meninges, allowing myeloid and lymphoid cells to migrate. We hypothesized that these direct channels may also allow brain drug delivery from the skull bone marrow to the brain. In this study, for the first time we propose intraosseous administration of drugs into the skull (intracal

SUBMITTER: Kang JH 

PROVIDER: S-EPMC10013776 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature