Fibrotic remodeling and tissue regeneration mechanisms define the therapeutic potential of human muscular progenitors.

ABSTRACT: Fibrosis is an intrinsic biological reaction toward the challenges of tissue injury that is implicated in the wound-healing process. Although it is useful to efficiently mitigate the damage, progression of fibrosis is responsible for the morbidity and mortality occurring in a variety of diseases. Because of lacking effective treatments, there is an emerging need for exploring antifibrotic strategies. Cell therapy based on stem/progenitor cells is regarded as a promising approach for treating fibrotic diseases. Appropriate selection of cellular sources is required for beneficial results. Muscle precursor cells (MPCs) are specialized progenitors harvested from skeletal muscle for conducting muscle regeneration. Whether they are also effective in regulating fibrosis has seldom been explored a

SUBMITTER: Hsiao YC 

PROVIDER: S-EPMC10013817 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature