Electrostatic potential difference between tumor and paratumor regulates cancer stem cell behavior and prognose tumor spread.

ABSTRACT: Tumor spread is responsible for most deaths related to cancer. Increasing the accuracy of cancer prognosis is critical to reducing the high mortality rates in cancer patients. Here, we report that the electrostatic potential difference (EPD) between tumor and its paratumor tissue is a prognostic marker for tumor spread. This finding is concluded from the patient-specific EPD values and clinical observation. The electrostatic potential values were measured on tissue cryosections from 51 patients using Kelvin probe force microscopy (KPFM). A total of ~44% (15/34) patients of V_{tumor-paratumor} > 0 were featured with tumor spread, whereas only ~18% (2/11) patients of V_{tumor-paratumor} < 0 had tumor spread. Next, we found the increased enrichment of cancer stem cells in para

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10013821 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature