Electrically regulated cell-based intervention for viral infections.

ABSTRACT: This work reports on an engineered cell that-when electrically stimulated-synthesizes a desired protein, that is, ES-Biofactory. The platform has been used to express interferon (IFN)-β as a universal antiviral protein. Compelling evidence indicates the inevitability of new pandemics and drives the need for a pan-viral intervention that may be quickly deployed while more specific vaccines are in development. Toward this goal, a fast-growing mammalian cell (Chassis) has been engineered with multiple synthetic elements. These include-(1) a voltage-gated Ca²⁺ channel (Voltage-Sensor) that, upon sensing the electric field, activates the (2) Ca²⁺-mediated signaling pathway (Actuator) to upregulate (3) IFN-β, via an engineered antiviral transgene

SUBMITTER: Newmyer S 

PROVIDER: S-EPMC10013824 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature