Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.

ABSTRACT: Periodontitis induced by chronic subgingival infection is a ubiquitous disease that causes systemic inflammatory consequences and poses a negative impact on quality of life. The disease is treated and potentially prevented by patient's self-care aimed at eliminating the oral pathogens from the region. Currently available products for interdental self-care, including dental floss and interdental brush, have limited ability to prevent the disease. Here, we report a coated dental floss thread, termed "nanofloss," which uses polyphenol-based nanocoating to functionalize the floss thread with therapeutic agents. Multiple therapeutics can be integrated into the nanofloss including antibacterial small molecules and proteins. Flossing with nanofloss-delivered therapeutic agents to the challenging

SUBMITTER: Nakajima M 

PROVIDER: S-EPMC10013826 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature