Competing constraints shape the nonequilibrium limits of cellular decision-making.

ABSTRACT: Gene regulation is central to cellular function. Yet, despite decades of work, we lack quantitative models that can predict how transcriptional control emerges from molecular interactions at the gene locus. Thermodynamic models of transcription, which assume that gene circuits operate at equilibrium, have previously been employed with considerable success in the context of bacterial systems. However, the presence of ATP-dependent processes within the eukaryotic transcriptional cycle suggests that equilibrium models may be insufficient to capture how eukaryotic gene circuits sense and respond to input transcription factor concentrations. Here, we employ simple kinetic models of transcription to investigate how energy dissipation within the transcriptional cycle impacts the rate at which gen

SUBMITTER: Lammers NC 

PROVIDER: S-EPMC10013869 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature