Influenza A virus coinfection dynamics are shaped by distinct virus-virus interactions within and between cells.

ABSTRACT: When multiple viral populations propagate within the same host environment, they often shape each other's dynamics. These interactions can be positive or negative and can occur at multiple scales, from coinfection of a cell to co-circulation at a global population level. For influenza A viruses (IAVs), the delivery of multiple viral genomes to a cell substantially increases burst size. However, despite its relevance for IAV evolution through reassortment, the implications of this positive density dependence for coinfection between distinct IAVs has not been explored. Furthermore, the extent to which these interactions within the cell shape viral dynamics at the level of the host remains unclear. Here we show that, within cells, diverse coinfecting IAVs strongly augment the replication of a

SUBMITTER: Delima GK 

PROVIDER: S-EPMC10013887 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature