A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex.

ABSTRACT: Substantial progress in the field of neuroscience has been made from anaesthetized preparations. Ketamine is one of the most used drugs in electrophysiology studies, but how ketamine affects neuronal responses is poorly understood. Here, we used in vivo electrophysiology and computational modelling to study how the auditory cortex of bats responds to vocalisations under anaesthesia and in wakefulness. In wakefulness, acoustic context increases neuronal discrimination of natural sounds. Neuron models predicted that ketamine affects the contextual discrimination of sounds regardless of the type of context heard by the animals (echolocation or communication sounds). However, empirical evidence showed that the predicted effect of ketamine occurs only if the acoustic context consists of low-pit

SUBMITTER: Lopez-Jury L 

PROVIDER: S-EPMC10013928 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature