Dataset Information

Rational Design of Organelle-Targeted Fluorescent Probes: Insights from Artificial Intelligence.

ABSTRACT: Monitoring the physiological changes of organelles is essential for understanding the local biological information of cells and for improving the diagnosis and therapy of diseases. Currently, fluorescent probes are considered as the most powerful tools for imaging and have been widely applied in biomedical fields. However, the expected targeting effects of these probes are often inconsistent with the real experiments. The design of fluorescent probes mainly depends on the empirical knowledge of researchers, which was inhibited by limited chemical space and low efficiency. Herein, we proposed a novel multilevel framework for the prediction of organelle-targeted fluorescent probes by employing advanced artificial intelligence algorithms. In this way, not only the targeting mechanism could be interpreted beyond intuitions but also a quick evaluation method could be established for the rational design. Furthermore, the targeting and imaging powers of the optimized and synthesized probes based on this methodology were verified by quantitative calculation and experiments.

SUBMITTER: Dong J

PROVIDER: S-EPMC10013958 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Rational Design of Organelle-Targeted Fluorescent Probes: Insights from Artificial Intelligence.

Dong Jie J Qian Jie J Yu Kunqian K Huang Shuai S Cheng Xiang X Chen Fei F Jiang Hualiang H Zeng Wenbin W

Research (Washington, D.C.) 20230308

Monitoring the physiological changes of organelles is essential for understanding the local biological information of cells and for improving the diagnosis and therapy of diseases. Currently, fluorescent probes are considered as the most powerful tools for imaging and have been widely applied in biomedical fields. However, the expected targeting effects of these probes are often inconsistent with the real experiments. The design of fluorescent probes mainly depends on the empirical knowledge of ...[more]

PMID: 36930810

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Project description:The floor plan layout of museum exhibition spaces is the skeleton network of the museum, which determines the internal circulation and spatial form of the museum. This paper studies the method and practice of using artificial intelligence technology to assist in the space design of exhibition halls in urban cultural museums. First, it introduces the limitations of traditional space design methods for exhibition halls in urban cultural museums and the superiority and application prospects of the CGAN (conditional generative adversarial network) model in space design. Second, the principle and training process of the CGAN model are explained in detail, and the experimental results and analysis are given. By learning 100 floor plans of exhibition halls of urban culture museums, the CGAN model can generate a new floor plan design for an exhibition hall, which provides a new idea and innovative method for this design task. Finally, the limitations and future research directions of the CGAN model in the space design of urban cultural museum exhibition halls are discussed. The study shows that using the CGAN model to learn the floor plans of exhibition halls of urban cultural museums can effectively improve the innovation and practicability of space design and has the following advantages: (1) It can quickly generate a large number of exhibition hall floor plans, shorten the design cycle, and improve design efficiency. (2) The generated floor plan designs of the exhibition hall are diverse and personalized, meeting the design requirements of different scenarios and needs. (3) The method promotes the deep integration of space design and artificial intelligence technology and provides new possibilities and ideas for space design. These conclusions provide new ideas and methods for the space design of exhibition halls of urban cultural museums and provide a reference and inspiration for space design and intelligent applications in other fields, such as office space design, home decoration space design, landscape space design, and historical arcade and building renovation design.

Dataset Information

Rational Design of Organelle-Targeted Fluorescent Probes: Insights from Artificial Intelligence.

Publications

Rational Design of Organelle-Targeted Fluorescent Probes: Insights from Artificial Intelligence.

Similar Datasets

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