Secondary infections in critically ill patients with viral pneumonia due to COVID-19 and influenza: a historical cohort study.

ABSTRACT:

Purpose

To compare the incidence and nature of secondary infections (SI) between critically ill patients with viral pneumonia due to COVID-19 and seasonal influenza and explore the association between SI and clinical outcomes.

Methods

We conducted a historical cohort study of patients admitted to the intensive care unit (ICU) at two tertiary care centers during the first wave of the COVID-19 pandemic and patients admitted with influenza during the 2018-2019 season. The primary outcome was the rate of SI. Secondary outcomes included rates of ICU and in-hospital mortality, organ-support-dependent disease, and length of ICU and hospital stay.

Results

Secondary infections developed in 55% of 95 COVID-19 patients and 51% of 47 influenza patients (unadjusted odds ratio [OR]

SUBMITTER: Beliavsky A 

PROVIDER: S-EPMC10013978 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature