No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury.

ABSTRACT:

Background

Opioids effectively reduce chronic pain, but present significant side effects including opioid-induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied.

Methods

We assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55-year-old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively.

Results

Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity.

Interpretation

Oxycodone/naloxone was effective in managing chronic pain and constipa

SUBMITTER: Sachdeva R 

PROVIDER: S-EPMC10014000 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature