White matter hyperintensity, neurofilament light chain, and cognitive decline.

ABSTRACT:

Objective

We aimed to determine whether combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition in older adults.

Methods

Utilizing data from the population-based Chicago Health and Aging Project, we studied 701 individuals with both biomarkers and cognitive data during the follow-up period. NfL was measured using an ultrasensitive immunoassay, single-molecule array technology. MRI scans of the brain were acquired using 1.5-T systems. Global cognitive function was created as a composite measure of four neuropsychological tests, standardized and averaged to z-scores. Multivariable linear mixed-effects models were used to evaluate the association of WMH and NfL with the rate of cognitive decline.

Res

SUBMITTER: Dhana A 

PROVIDER: S-EPMC10014007 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature