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Thermodynamic Control of Activity Patterns in Cytoskeletal Networks.

ABSTRACT: Biological materials, such as the actin cytoskeleton, exhibit remarkable structural adaptability to various external stimuli by consuming different amounts of energy. In this Letter, we use methods from large deviation theory to identify a thermodynamic control principle for structural transitions in a model cytoskeletal network. Specifically, we demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components effectively renormalizes the interaction strength between such components, which can eventually result in a morphological transition. Our work demonstrates how a thermodynamic quantity can be used to renormalize effective interactions, which in turn can tune structure in a predictable manner, suggesting a thermodynamic principle for the control of cytoskeletal structure and dynamics.

SUBMITTER: Lamtyugina A

PROVIDER: S-EPMC10014041 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Thermodynamic Control of Activity Patterns in Cytoskeletal Networks.

Lamtyugina Alexandra A Qiu Yuqing Y Fodor Étienne É Dinner Aaron R AR Vaikuntanathan Suriyanarayanan S

Physical review letters 20220901 12

Biological materials, such as the actin cytoskeleton, exhibit remarkable structural adaptability to various external stimuli by consuming different amounts of energy. In this Letter, we use methods from large deviation theory to identify a thermodynamic control principle for structural transitions in a model cytoskeletal network. Specifically, we demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components effectively renormalizes the interaction strength betw ...[more]

PMID: 36179154

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