Regenerative Potential of Granulation Tissue in Periodontitis: A Systematic Review and Meta-analysis.

ABSTRACT:

Methods

Electronic searches were conducted in five databases including CENTRAL, MEDLINE, EMBASE, Web of Science, and Dentistry & Oral Sciences Source using a combination of MeSH terms and keywords up to 21 June 2022. Human studies including patients aged over 18 years with all forms of periodontitis were included. Following the risk of bias assessment, both qualitative and quantitative analyses were performed.

Results

A total of twelve studies were included in qualitative analysis and six of them in quantitative analyses. The evidence suggested that cells derived from periodontitis granulation tissue have osteogenic, adipogenic, chondrogenic, neurogenic, and angiogenic differentiation abilities as well as immunoregulatory properties. In particular, CD44⁺, CD73

SUBMITTER: Tan N 

PROVIDER: S-EPMC10014158 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature