Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice.

ABSTRACT:

Background

The intestinal microbiota is an important regulator of bone health. In previous studies we have shown that intestinal microbiota dysbiosis, induced by treatment with broad spectrum antibiotics (ABX) followed by natural repopulation, results in gut barrier dysfunction and bone loss. We have also shown that treatment with probiotics or a gut barrier enhancer can inhibit dysbiosis-induced bone loss. The overall goal of this project was to test the effect of Korean Red Ginseng (KRG) extract on bone and gut health using antibiotics (ABX) dysbiosis-induced bone loss model in mice.

Methods

Adult male mice (Balb/C, 12-week old) were administered broad spectrum antibiotics (ampicillin and neomycin) for 2 weeks followed by 4 weeks of natural repopulation. During this 4-week

SUBMITTER: Kang HJ 

PROVIDER: S-EPMC10014174 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature