Impact of pharmacogenetics on aspirin resistance: a systematic review.

ABSTRACT:

Background

Pharmacogenetics promises better control of diseases such as cardiovascular disease (CVD). Acetylsalicylic acid, aspirin, prevents the formation of an activating agent of platelet aggregation and vasoconstriction, and it is used to prevent CVD. Nevertheless, patients may have treatment failure due to genetic variants that modify the metabolism of the drug causing aspirin resistance (AR).

Objectives

To realize a systematic literature review to determine the impact of genetic variants on AR.

Methods

Articles published in the MEDLINE/PubMed, Cochrane, Scopus, LILACS, and SCIELO databases were systematically screened. A total of 290 articles were identified and 269 articles were excluded because they did not comply with the previously established inclusion crit

SUBMITTER: Silva GFD 

PROVIDER: S-EPMC10014202 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature