Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease.

ABSTRACT: Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in models of aging and neurodegenerative diseases, including Parkinson's disease (PD). Although generally considered safe, concerns have been raised that NR supplementation could impact methylation dependent reactions, including DNA methylation, because of increased production and methylation dependent breakdown of nicotinamide (NAM). We investigated the effect of NR supplementation on DNA methylation in a double blinded, placebo-controlled trial of 29 human subjects with PD, in blood cells and muscle tissue. Our results show that NR had no impact on DNA methylation homeostasis, including individuals with common pathogenic mutations in the

SUBMITTER: Gaare JJ 

PROVIDER: S-EPMC10014306 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature