Early Ultrastructural Changes in Biopsies From Patients With Symptomatic CKD of Uncertain Etiology.

ABSTRACT:

Introduction

Although the investigation of chronic kidney disease of uncertain etiology (CKDu) has identified many possible influencing factors in recent years, the exact pathomechanism of this disease remains unclear.

Methods

In this study, we collected 13 renal biopsies from patients with symptomatic CKDu (Sym-CKDu) from Sri Lanka with well-documented clinical and socioeconomic factors. We performed light microscopy and electron microscopic evaluation for ultrastructural analysis, which was compared with 100 biopsies from German patients with 20 different kidney diseases.

Results

Of the 13 Sri Lankan patients, 12 were men (92.3%), frequently employed in agriculture (50%), and experienced symptoms such as feeling feverish (83.3%), dysuria (83.3%), and arthralgia (66.

SUBMITTER: Daniel C 

PROVIDER: S-EPMC10014386 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature