Elevated Urinary IL-6 Predicts the Progression of IgA Nephropathy.

ABSTRACT:

Introduction

Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. However, biomarkers for predicting the progression or regression of IgAN remain a clinical challenge. In the present study, we aim to identify promising prognostic markers of IgAN.

Methods

Using the cytokine antibody array, we detected serum and urinary levels of 9 common cytokines selected from 23 IgAN-related biomarkers in 32 patients with IgAN and 16 healthy controls. The best biomarkers for distinguishing IgAN patients from healthy controls were identified and confirmed in a multicenter cohort with 222 patients with IgAN and 159 age- and sex-matched healthy controls. Their associations with IgAN progression were further explored in 762 patients with IgAN with a median follow

SUBMITTER: Zhao W 

PROVIDER: S-EPMC10014388 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature