Intrahepatic infiltration of activated CD8⁺ T cells and mononuclear phagocyte is associated with idiosyncratic drug-induced liver injury.

ABSTRACT:

Background

Idiosyncratic drug-induced liver injury (DILI) is caused by the interplay among drugs, their metabolites, and the host immune response. The characterization of infiltrated immune cells in the liver may improve the understanding of the pathogenesis of idiosyncratic DILI. This study investigated the phenotypes and clinical implications of liver-infiltrating immune cells in idiosyncratic DILI.

Methods

From January 2017 to June 2021, 53 patients with idiosyncratic DILI who underwent liver biopsy were prospectively enrolled in this study. Immunohistochemical staining and flow cytometry analyses were performed on the biopsy specimens. Serum levels of CXC chemokine ligand 10 (CXCL10) and soluble CD163 were measured. A multivariate cox proportional hazards model was used

SUBMITTER: Yang H 

PROVIDER: S-EPMC10014460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature