Mechanosensitive channel MscL induces non-apoptotic cell death and its suppression of tumor growth by ultrasound.

ABSTRACT: Mechanosensitive channel of large conductance (MscL) is the most thoroughly studied mechanosensitive channel in prokaryotes. Owing to its small molecular weight, clear mechanical gating mechanism, and nanopore forming ability upon opening, accumulating studies are implemented in regulating cell function by activating mechanosensitive channel of large conductance in mammalian cells. This study aimed to investigate the potentials of mechanosensitive channel of large conductance as a nanomedicine and a mechano-inducer in non-small cell lung cancer (NSCLC) A549 cells from the view of molecular pathways and acoustics. The stable cytoplasmic vacuolization model about NSCLC A549 cells was established via the targeted expression of modified mechanosensitive channel of large conductance chan

SUBMITTER: Wen X 

PROVIDER: S-EPMC10014542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature