Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes.

ABSTRACT: Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly and subsequent chromosome segregation. The mechanism and function of chromosome clustering are unknown. Here we show that chromosome clustering is required to prevent chromosome losses in the long gap phase between nuclear envelope breakdown and the onset of spindle assembly, and to promote the rapid capture of all chromosomes by the acentrosomal spindle. The initial phase of chromosome clustering is driven by a dynamic network of Formin-2- and Spire-nucleated actin cables. The actin cables form in the disassembling nucleus and migrate towards the nuclear centre, moving the chromosomes centripetally by interacting w

SUBMITTER: Harasimov K 

PROVIDER: S-EPMC10014578 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature