Computational comparative analysis identifies potential stemness-related markers for mesenchymal stromal/stem cells.

ABSTRACT: Mesenchymal stromal/stem cells (MSCs) are multipotent cells that reside in multiple tissues are capable of self-renewal and differentiation into various cell types. These properties make them promising candidates for regenerative therapies. MSC identification is critical in yielding pure populations for successful therapeutic applications; however, the criteria for MSC identification proposed by the International Society for Cellular Therapy (ISCT) are inconsistent across different tissue sources. This study aimed to identify potential markers to be used together with the ISCT criteria to provide a more accurate means of MSC identification. Thus, we carried out a computational comparative analysis of the gene expression in human and mouse MSCs derived from multiple tissues to identify the

SUBMITTER: Ghabriel M 

PROVIDER: S-EPMC10014615 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature