Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors.

ABSTRACT: Cancer is one of the three leading causes of death worldwide. Even after successful therapy and achieving remission, the risk of relapse often remains. In this context, dormant residual cancer cells in secondary organs such as the bone marrow constitute the cellular reservoir from which late tumor recurrences arise. This dilemma leads the term of minimal residual disease, which reflects the presence of tumor cells disseminated from the primary lesion to distant organs in patients who lack any clinical or radiological signs of metastasis or residual tumor cells left behind after therapy that eventually lead to local recurrence. Disseminated tumor cells have the ability to survive in a dormant state following treatment and linger unrecognized for more than a decade before emerging as recurre

SUBMITTER: Heidrich I 

PROVIDER: S-EPMC10014694 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature