Effects of allicin on human Simpson-Golabi-Behmel syndrome cells in mediating browning phenotype.

ABSTRACT:

Introduction

Obesity is a major health problem because it is associated with increased risk of cardiovascular disease, diabetes, hypertension, and some cancers. Strategies to prevent or reduce obesity focus mainly on the possible effects of natural compounds that can induce a phenotype of browning adipocytes capable of releasing energy in the form of heat. Allicin, a bioactive component of garlic with numerous pharmacological functions, is known to stimulate energy metabolism.

Methods

In the present study, the effects of allicin on human Simpson-Golabi-Behmel Syndrome (SGBS) cells were investigated by quantifying the dynamics of lipid droplets (LDs) and mitochondria, as well as transcriptomic changes after six days of differentiation.

Results

Allicin significantly pro

SUBMITTER: Ali U 

PROVIDER: S-EPMC10014806 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature