Impact of severe secondary tricuspid regurgitation on rest and exercise hemodynamics of patients with heart failure and a preserved left ventricular ejection fraction.

ABSTRACT:

Background

Both secondary tricuspid regurgitation (STR) and heart failure with preserved ejection fraction (HFpEF) are relevant public health problems in the elderly population, presenting with potential overlaps and sharing similar risk factors. However, the impact of severe STR on hemodynamics and cardiorespiratory adaptation to exercise in HFpEF remains to be clarified.

Aim

To explore the impact of STR on exercise hemodynamics and cardiorespiratory adaptation in HFpEF.

Methods

We analyzed invasive hemodynamics and gas-exchange data obtained at rest and during exercise from HFpEF patients with severe STR (HFpEF-STR), compared with 1:1 age-, sex-, and body mass index (BMI)- matched HFpEF patients with mild or no STR (HFpEF-controls).

Results

Twelve HFpEF with

SUBMITTER: Baratto C 

PROVIDER: S-EPMC10014840 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature