A large-scale screening and functional sorting of tumour microenvironment prognostic genes for breast cancer patients.

ABSTRACT:

Purpose

The aim of this study was to systematically establish a comprehensive tumour microenvironment (TME)-relevant prognostic gene and target miRNA network for breast cancer patients.

Methods

Based on a large-scale screening of TME-relevant prognostic genes (760 genes) for breast cancer patients, the prognostic model was established. The primary TME prognostic genes were selected from the constructing database and verified in the testing database. The internal relationships between the potential TME prognostic genes and the prognosis of breast cancer patients were explored in depth. The associated miRNAs for the TME prognostic genes were generated, and the functions of each primary TME member were investigated in the breast cancer cell line.

Results

Compared with si

SUBMITTER: Xiao B 

PROVIDER: S-EPMC10014861 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature