Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC10014883 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Du Jiahui J Liu Yili Y Wu Xiaolin X Sun Jinrui J Shi Junfeng J Zhang Hongming H Zheng Ao A Zhou Mingliang M Jiang Xinquan X
Nature communications 20230314 1
Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF chromatin remodeling complex, has been identified as a critical therapeutic target in hematological diseases. Despite the hematopoietic origin of osteoclasts, the role of BRD9 in osteoclastogenesis and bone diseases remains unresolved. Here, we show Brd9 deficiency in myeloid lineage enhances osteoclast lineage commitment and bone resorption through downregulating interferon-beta (IFN-β) signaling with released constraint ...[more]