Altered cell function and increased replication of rhinoviruses and EV-D68 in airway epithelia of asthma patients.

ABSTRACT:

Introduction

Rhinovirus (RV) infections constitute one of the main triggers of asthma exacerbations and an important burden in pediatric yard. However, the mechanisms underlying this association remain poorly understood.

Methods

In the present study, we compared infections of in vitro reconstituted airway epithelia originating from asthmatic versus healthy donors with representative strains of RV-A major group and minor groups, RV-C, RV-B, and the respiratory enterovirus EV-D68.

Results

We found that viral replication was higher in tissues derived from asthmatic donors for all tested viruses. Viral receptor expression was comparable in non-infected tissues from both groups. After infection, ICAM1 and LDLR were upregulated, while CDHR3 was downregulated. Overall

SUBMITTER: Essaidi-Laziosi M 

PROVIDER: S-EPMC10014885 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature